COVID-19 in a cohort of pregnant women and their descendants, the MOACC-19 study. The Mother and Child COVID-19 study is a cohort recruiting pregnant women and their children in Spain, during the COVID-19 pandemic to understand the consequences of SARS-CoV-2 infection on pregnant women and their descendants. This recruitment is still open. Three cohorts will include women likely infected during different phases of pregnancy. All women are being tested using both RT-PCR for COVID-19 RNA and ELISA for anti-SARS-CoV-2 antibodies. All neonates are being tested for antibodies; if the mother tests positive for SARS-CoV-2 RNA, a nasopharyngeal swab will be obtained from the child for RT-PCR. As of October 22, 2020, 1167 women have been recruited. Fourteen women tested positive to SARS-CoV-2 RNA , but their infants all tested negative for this RNA. All children in the study will be followed by for 1 year.
Cause of preterm birth and late-onset sepsis in very preterm infants: the EPIPAGE-2 cohort study. The risk factors and pathogenesis of late-onset sepsis (LOS) in preterm infants is poorly understood. This study included 2052 very preterm singletons from a national population-based cohort study alive at 72 h of life were included; 437 (20.1%) had at least one episode of LOS. The authors show that very preterm infants born after hypertensive disorders or born after FGR had an increased risk of LOS compared to those born after preterm labor. Therefore, antenatal factors, in particular the full spectrum of causes leading to preterm birth, should be taken into consideration to better prevent and manage neonatal infectious morbidity and inform the parents.
Middle-East OBGYN Graduate Education (MOGGE) Foundation practice guidelines: prevention of group B Streptococcus infection in pregnancy and in newborn. Practice guideline no. 02-O-20. Rectovaginal colonization with group B streptococcus (GBS) is commonly encountered in pregnancy. GBS is the most common cause of early onset neonatal sepsis, which is associated with 12% case-fatality rate. Although screening protocols and prophylactic treatment are readily available worldwide, practice in low-resource countries is challenged by lack of awareness and limited implementation of these protocols. In addition, antibiotic susceptibility pattern may vary globally owing to different regulations of antibiotic prescription or prevalence of certain bacterial serotypes. This guideline appraises current evidence on GBS colonization in pregnancy particularly in low-resource settings.